Birth Defects from Drugs

Medication for Pregnant WomanToday there is generally widespread public awareness that using illegal drugs and alcohol during pregnancy can cause serious developmental birth defects. However, the use of certain prescription drugs during pregnancy can cause birth defects. Below are prescription medications linked to birth defects.

Serotonin Reuptake Inhibitors 

Selective serotonin reuptake inhibitors (SSRIs) are some of the most widely utilized drugs in the field of mental health. Millions of people take SSRIs for the treatment of depression and anxiety. Until fairly recently SSRIs were considered safe during pregnancy.

However, a number of studies were released which demonstrated that certain drugs in the SSRI category during pregnancy created a risk of newborn hypertension; spina bifida, heart defects, and other birth defects. The SSRI drugs that cause these problems include Zoloft, Lexapro, Prozac, Paxil, Symbax, Fluvoxamine.


Benzodiazepines are psychoactive drugs that have been in use since the 1950s. Benzodiazepines work by boosting the effectiveness of certain chemical electrical activities within the brain that trigger feelings of calm. Benzodiazepines are widely prescribed for the treatment of various mental health conditions such as anxiety and insomnia. They are also used to control seizures in people with epilepsy or cerebral palsy. The use of benzodiazepines during pregnancy has been definitively linked to developmental birth defects involving lack of muscle control and respiratory problems.


Accutane is a synthetic form of Vitamin A that is primarily prescribed for the treatment of severe acne.  Isotretinoin is the active ingredient in this medication. 

Accutane is high on the list of drugs that cause birth defects.   Numerous studies demonstrate the drug causes birth defects and stillbirth if used during pregnancy.

According to the FDA safety data, continued use of Accutane during pregnancy will result in as much as a 35% chance of having a baby born with a birth defect. The chances of having a baby with a birth defect normally are less than 1%. In fact, Accutane is so potentially harmful to unborn children that women should stop using the drug three years before a planned pregnancy.


Most first-generation antibiotics are completely safe for use during pregnancy. These include well-known drugs such as amoxicillin, penicillin, ampicillin, and clindamycin. However, recent studies have established a potential link between a particular group of advanced antibiotics and certain developmental birth defects including cleft lip, heart defects, and a skull malformation called anencephaly. The specific antibiotics linked to these birth defects are listed below:

  • Nitrofurantoin: a newer type of antibiotic that is often used to treat chronic or difficult urinary tract infections. The drug is also used for the treatment of bladder inflammation.
  • Sulfonamides: sulfonamides are actually one of the earliest forms of antibiotics. Known as bacteriostatic antibiotics they contain chemicals from the sulfonamide group. They work by preventing bacteria cells from synthesizing folic acid which they need to grow and multiply. Popular drugs in this group include Gantrisin, Bactrim (Septra), Sulfadiazine, and Zonegran.
  • Tetracyclines: tetracyclines are broad-spectrum polyketide antibiotics that are particularly effective against certain types of bacteria. Use of tetracyclines has decreased in recent years because of problems with resistance. These antibiotics are primarily used for the treatment of acne rosacea and certain sexually transmitted diseases. Popular brand name drugs of this type include Solodyn, Doryx, Vibramycin, Oracea, and Monodox.
Fluconazole / Diflucan

Fluconazole (brand name Diflucan) is a very popular antifungal medication that has been in use since the 1990s. Fluconazole is usually prescribed for the treatment of yeast infections in women and other types of fungal infections. When used during pregnancy fluconazole can significantly increase the risk of having a miscarriage.


NSAIDs (non-steroidal anti-inflammatory drugs) include many of the most widely used over-the-counter pain fever-reducing medications in the world. Millions of people used NSAIDs regularly. NSAIDs include any ibuprofen-based pain relief drug. The most popular over-the-counter NSAIDs include Motrin, Aleve, and Excedrin.

Prescription-strength NSAIDs include Diclofenac, Lodine, and Meloxicam. Some studies have shown that NSAIDs present a small risk of neural tube and other birth defects. Although these risks are very small, women who are pregnant or planning to become pregnant should probably use alternative medications such as Tylenol.


Anticonvulsants are drugs are used to help prevent or control various types of seizures. Research has shown that a handful of anti-seizure medications are linked to increased rates of certain birth defects such as organ abnormalities, cleft lips, and developmental delays. The particular anticonvulsant drugs linked with this risk include Tegretol, Depakote, Lamictal, and Dilantin. Unfortunately controlling seizures in pregnant women is also important to the health of the baby because certain types of seizures are known to trigger miscarriages.

Additional Information About Drugs & Pregnancy

For more detailed information about what medications cause birth defects, including the research and studies behind various safety warnings, visit the Centers for Disease Control's web page on safe medication use during pregnancy. Finally, Internet research is great but always consult with your doctor on what is best for you and your condition.