Anti-Seizure Drugs for Kids With Cerebral Palsy

Child PharmaceuticalsCerebral palsy is primarily a movement disorder in which the brain is not able to control and direct the movement of certain muscles in the body. However, children with cerebral palsy typically suffer from one or more additional physical problems known as co-occurring conditions. Epileptic seizures are the second most common type of co-occurring condition in kids with all types of cerebral palsy. Approximately 35% of people with cerebral palsy suffer from frequent seizures and/or epilepsy.

The frequency and severity of seizures in CP children varies dramatically. Some children with CP may experience a few minor seizures a year while others may have dozens of major seizures every day. Seizures can be a particularly difficult condition for children with cerebral palsy. They are not only uncomfortable and disruptive but they can actually lead to dangerous situations and accidents. For this reason minimizing or eliminating the occurrence and intensity of seizures is often a primary goal of cerebral palsy treatment plans. Although the underlying cause of cerebral palsy itself cannot be effectively treated with drugs, prescription medications can be very successful in preventing seizures. Below is a general description of the primary medications currently utilized in the treatment of seizures in children with cerebral palsy.

Phenobarbital

Phenobarbital is properly the most widely utilized and well known prescription drugs given to children with all types of cerebral palsy. Phenobarbital belongs to a class of drugs known as barbiturates. All barbiturates work by essentially slowing down or relaxing certain types of brain activity. For children with cerebral palsy phenobarbital is used as an anticonvulsant which blocks or minimizes the neurologic actions that trigger seizures. It also has the side benefit of being a sleeping aid. Phenobarbital comes in tablets or liquid form and typically must be taken multiple times daily. Of all the various anti-seizure drugs used in CP treatment, Phenobarbital has the longest track record of success.

  • Problems / Side Effects: the primary problem with Phenobarbital (as well as other barbiturates) is that it is habit-forming. Children taking the drug tend to become addicted and suffer from withdraw if they stop taking it. Long-term use of the drug also leads to build up of drug tolerance requiring increasingly higher doses to accomplish the same results. Tolerance problems with Phenobarbital make long-term use very problematic. Most frequently reported side-effects include anxiety, withdraw, chronic constipation and low blood pressure.
Clonazepam

Clonazepam (also known by U.S. brand name Klonopin) is a family of drugs known as benzodiazepines. Clonazepam and other benzodiazepine drugs work by curtailing abnormal electrical impulses within the brain. The drug is most frequently used to control epileptic seizures in children with cerebral palsy who are epileptic. Clonazepam is also a strong muscle relaxant and sleeping aid which makes it highly beneficial for kids with spastic cerebral palsy where excessive muscle tone is a primary symptom.

  • Problems / Side Effects: Clonazepam is another drug that is known to be very addictive. Children who take the drug for an extended period of time will eventually develop a high level of drug tolerance making it less and less effective at the original dosage. Another notable drawback of Clonazepam is that causes significant lethargy.
Phenytoin

CP Co-Occuring ConditionsPhenytoin (also known by the brand name Dilantin) is classified as an anticonvulsant and it helps prevent seizures by limiting certain types of electrical impulses within the brain. Unlike the other more powerful drugs described above, Dilantin only helps with specific types of seizures. Dilantin is effective against epileptic seizures such as tonic-clonic or so called "grand mal" seizures. However, the drug is not useful for preventing absence / drop seizures and can actually make these types of seizures occur more frequently. One of the primary benefits of Dilantin over other drugs is that it is not addictive.

  • Problems / Side Effects: Dilantin is not potentially habit forming so tolerance and addiction are not a problem. The number one drawback of this drug is that it sometimes causes trouble sleeping. This is a big deal for children with cerebral palsy who frequently have difficulty with normal sleeping to begin with. It can also interfere with speech and oral motor control - also a big drawback for a child with CP who already has speech abnormalities.
Carbamazepine

Carbamazepine is better known by its U.S. brand name Tegretol and is classified as an anticonvulsant. Tegretol works by curbing certain types of electrical transmissions within the brain that are known to trigger seizures. Like Dilantin and other related anticonvulsants, Tegretol only works for the type of seizures typically associated with epilepsy. Tegretol is not useful for preventing other types of seizures such as absence seizures and myoclonic seizures. Tegretol is not habit-forming which makes it a safer, less problematic alternative to the more powerful drugs used to prevent seizures.

  • Problems / Side Effects: There are certain children who cannot use Tegretol because it is known to cause a rare and potentially fatal allergic reaction called Stevens-Johnson syndrome/toxic epidermal necrolysis in which the skin literally decays and falls off. Researchers have linked this allergic reaction risk to a genetic predisposition in people of Asian ethnicity so a genetic test is usually done before the drug is prescribed.