Blighted Ovum Miscarriage

Embryonic DevelopmentA blighted ovum is a type of miscarriage that occurs very early in pregnancy in which the fertilized egg is not able to develop into an embryo after it has attached itself to the uterine wall. This type of miscarriage usually occurs within the very early stages of pregnancy (weeks 2-6), often before a woman even knows she's pregnant.

Without or without prior knowledge of the pregnancy, losing a developing fetus so early in the process can be devastating. Fortunately this is not an uncommon event and having an early miscarriage like this does not have any impact on having a healthy pregnancy in the future. Read below to find out about the causes of blighted ovum, treatment for it, and the long-term outlook for fertility after miscarriage.

What is a Blighted Ovum?

A blighted ovum occurs very early in the process of embryonic development. When sperm reaches an egg, the egg becomes fertilized and begins the rapid production of new cells within only a few hours. With a normal pregnancy, the fertilized egg will grow from a clump of cells into an embryo by the 10th day of development. The embryo will then implant itself into the wall of the uterus. This triggers the release of high levels of pregnancy hormones in the body and causes the placenta to start developing to support the fetus. The fetus will continue to grow over the next few weeks, and around the 6th week of pregnancy, it will finally be visible on an ultrasound.

When blighted ovum occurs, this initial process is not successfully completed. Sometimes the fertilized egg is not able to develop into an embryo but still implants itself into the uterus. In other cases, the transition from fertilized egg to embryo was successful but the embryo stops developing a few days after attaching. In order for a doctor to diagnose a blighted ovum, an ultrasound will be performed and the doctor will identify an empty gestational sac with no signs of an embryo. The diagnosis can usually be confirmed by the 8th week of pregnancy when the embryo would normally be visible.

Causes of Blighted Ovum

From research conducted on multiple women who experienced a blighted ovum, there is a general consensus that the wide majority of miscarriages from this condition are due to abnormal chromosomes[2]. The fertilized egg or embryo might be missing chromosomes or developed too many, which disrupts the normal process of development. In rare cases, genetic mutations can also be a cause for a blighted ovum, specifically for embryos who stopped developing after attaching to the uterus.

A blighted ovum is similar to other miscarriages in the sense that there was some developmental abnormality that ultimately caused the pregnancy to fail. It can create feelings of loss and despair, but it's important to understand that there is no way to prevent it from happening and women should not blame themselves. For early miscarriages, there is often no way to know that something has gone wrong until your doctor identifies it.

How Common is Blighted Ovum?

Accurate occurrence rates for blight ovum are difficult because many women choose not to share their miscarriage stories out of shame or embarrassment. However, miscarriages are actually very common, with around 10-20% of pregnancies ending in miscarriage[4]. In that statistic, early miscarriages are most prevalent with 80% of them occurring within the first 12 weeks. Additionally, many women have one or multiple miscarriages before they have a normal pregnancy.

The statistics for how common blighted ovum is can be hard to measure due to difficulties diagnosing the condition. Since it occurs so early, women may not even know they were pregnant and do not notice the miscarriage happening. From what is known, experts believe blighted ovum accounts for a third of miscarriages that occur before 8 weeks gestation[3].

Symptoms of Blighted Ovum

Even though the embryo is not developing properly or has stopped altogether, a woman may experience early pregnancy symptoms since the body has recognized something attached to the uterus. Until the embryo has been expelled from the body, hormones are still being produced and pregnancy tests can have positive results. A woman may have morning sickness, bloating, sore breasts, and other common symptoms that show up during the first weeks of pregnancy. However, there are some signs that may indicate a woman has a blighted ovum or is experiencing a miscarriage:

  • Abnormal heavy bleeding
  • Severe abdominal cramping
  • An ultrasound that shows an amniotic sac is but is missing an embryo

Treatment for Blighted Ovum

After you have been diagnosed with a blighted ovum, there are a few different treatments available depending on how your body reacts to the attached egg or embryo. For some women, there may be no treatment at all, as the body recognizes that there is no development and naturally passes the embryo by expelling the contents of the uterus. In these cases, the miscarriage will be similar to a heavy period, which can feel completely normal for someone who is unaware they had a blighted ovum.

If the blighted ovum is diagnosed but the body still continues to act pregnant and releases hormones, your doctor may wait a few days to see if the body adjusts and eventually passes the embryo. If the body continues to keep the embryo attached despite no development, medication or surgery can be used to clear the contents of the uterus. Medication like Cytotec can induce a miscarriage which causes temporary heavy bleeding. A brief surgical procedure can be also be given by dilating the cervix and manually emptying the uterus.

Can I get Pregnant Again After a Blighted Ovum?

Miscarriages can be scary and make you feel like something is wrong with your fertility, but in most cases, this is not reality. Miscarriages are a natural part of pregnancies and often have no bearing on how fertile you are. Having one blighted ovum is usually no cause for concern and most likely you will be able to have a normal and healthy pregnancy in the future. In a 2009 study involving women with early miscarriages, around 80% were able to have a successful pregnancy within the next five years[1]. Treatments used for blighted ovum also have no negative effects on future pregnancies, even for surgical procedures.

If you have experienced multiple blighted ova or are struggling with miscarriages, there may be a different underlying problem, such as a hormone imbalance or genetic mutation. Your doctor can run tests to identify possible causes for complications in development.

Sources and Additional Reading

[1] Smith, L.P., Ewings, P.D., & Quinlan, C. (2009). Incidence of pregnancy after expectant, medical, or surgical management of spontaneous first trimester miscarriage: long term follow-up of miscarriage treatment (MIST) randomized controlled trial. BMJ, 2009; 339:b3827.

[2] Lathi, R. B., Mark, S. D., Westphal, L. M., & Milki, A. A. (2007). Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions. Journal of Assisted Reproduction and Genetics, 24(11), 521-524. doi:10.1007/s10815-007-9166-1

[3] Regan, L. (2000). Epidemiology and the medical causes of miscarriage. Department of Reproductive Science and Medicine. 14(5):839-54

[4] Horner-Johnson, W., Kulkarni-Rajasekhara, S., Darney, B. G., Dissanayake, M., & Caughey, A. B. (2017). Live birth, miscarriage, and abortion among U.S. women with and without disabilities. Disability and Health Journal, 10(3), 382-386.