Abnormal Cord Insertion
During pregnancy, mother and fetus are connected by the placenta and umbilical cord. This system, which runs from the interior of the uterus to the fetus' bellybutton, allows for the vital transfer of materials to and from the developing baby.
Normally, the umbilical cord attaches to the center of the placenta. Rarely, the umbilical cord does not attach, or "insert," in the proper location. Abnormal cord insertion is associated with vasa previa, a potentially dangerous complication.About the Placenta and Umbilical Cord
The placenta and umbilical cord are temporary organs, delivered along with the baby at birth, which allows for the transportation and exchange of materials between mother and fetus via blood vessels.
The umbilical cord is attached to the fetus at the bellybutton and consists of two arteries and a vein surrounded by protective tissue. It embeds itself into the center of the placenta which is in turn latched onto the interior of the mother's uterus.
Within the placenta, nutrients and oxygen pass from maternal blood vessels to fetal blood vessels. Conversely, waste products like carbon dioxide pass from fetal blood vessels to maternal blood vessels so they can be eliminated by the mother's body. The placenta facilitates exchange between blood vessels via diffusion, so fluids from the mother and fetus never mix.Types of Abnormal Cord Insertion
In a marginal cord insertion, which occurs in 8.5% of pregnancies, the umbilical cord attaches to the edge of the placenta instead of the central placental mass. The placenta is thinner at the edges, and therefore less able to structurally support the umbilical cord.
In a velamentous cord insertion (VCI), the umbilical blood vessels insert into the amniotic sac instead of the placenta. This type of abnormal cord insertion is less common, occurring in only .5-2.4% of pregnancies, but also more dangerous due to its connection with vasa previa.Vasa Previa and Velamentous Cord Insertion
In velamentous insertion scenarios, the vessels of the umbilical cord are partially removed from their usual protective covering. Additionally, blood vessels run through part of the amniotic sac, the membrane that contains the fetus, instead of traveling directly from the umbilical cord to the placenta.
This increases the likelihood of vasa previa, a rare complication in which fetal blood vessels are contained within the part of the amniotic sac directly above the cervix. Vasa previa becomes dangerous when a mother goes into labor.
In a vaginal birth, the amniotic sac ruptures and the baby moves through the cervix and out through the vagina. In a vasa previa pregnancy, fetal blood vessels rupture along with the amniotic sac, resulting in blood loss for the fetus and mother.
Vasa previa is detected by ultrasound, either as part of a routine checkup or when a mother complains of vaginal bleeding. An ultrasound device inserted into the vagina can see blood vessels present near the opening of the cervix.
If vasa previa is not diagnosed before vaginal delivery starts, there is a high likelihood of stillbirth. However, when diagnosed, doctors will closely monitor the pregnancy and schedule a c-section delivery, circumventing any risk of bleeding and producing a healthy baby.Other Consequences of Abnormal Cord Insertion
Velamentous cord insertion has more serious consequences than marginal cord insertion given that in cases of marginal cord insertion the umbilical cord is attached to the placenta in a more typical fashion.
Typically, marginal cord insertion has little negative effect. However, there is a high risk of hemorrhage, or blood loss, for infants with velamentous cord insertion because the umbilical blood vessels are unprotected by umbilical tissue.
In general, abnormal cord insertion can cause the placenta to develop abnormally. The growth of the fetus is dependent upon the health of the placenta. It can also cause high blood pressure, vascular compression, and thrombosis.
In addition to its link to vasa previa, there is a link between abnormal cord insertion and placenta previa, a condition in which the placenta attaches to the uterus close to or on top of the cervix, sometimes necessitating a c-section.Causes and Prevention of Abnormal Cord Insertion
Abnormal cord insertion cannot be prevented, but certain factors increase the risk of abnormal cord insertion occurring.
For example, one study found that abnormal cord insertion was present in 16.9% of pregnancies involving twins versus only 7.8% of pregnancies involving one baby. The use of assisted reproductive technologies such as in vitro fertilization likewise increased the risk of abnormal cord insertion.
It is possible for the umbilical cord to be missing one of its two arteries, which makes abnormal cord insertion more likely. Mothers who are more advanced in age, smoke, or have chronic diseases such as diabetes are also at risk.
Abnormal insertion of the umbilical cord may happen due to the migration of the placenta within the uterus. There is no standard location for the placenta. Instead, the placenta seeks out the area of the uterus with the best supply of blood and avoids areas with less supply. A change in the location of the placenta may cause the umbilical cord to insert in the wrong spot.Early Signs and Diagnosis of Abnormal Cord Insertion
Often, abnormal cord insertion produces no symptoms. Vaginal bleeding during pregnancy and slow fetal heart rate, however, may indicate abnormalities in the umbilical cord and placenta. Blood from the fetus is darker in color since it's less oxygenated compared to the mother's blood.
During routine ultrasound checkups throughout pregnancy, doctors can see if the umbilical cord has inserted in the wrong location. Doppler imaging is also used. Doctors will look for signs of other potential issues, such as vasa previa and placenta previa, as a part of their diagnosis.
Once a doctor detects that the umbilical cord has inserted in the wrong location, they will note the exact location of the insertion. In follow up visits, the doctor will look to see if anything has changed. A marginal insertion could become a velamentous insertion over time, for example.
In some cases, the abnormal insertion corrects itself and is not severe enough to be of much concern. In other cases, like with persistent velamentous insertion, the doctor will schedule a c-section at around 37 weeks of pregnancy.
If for some reason an abnormal cord insertion went undetected, especially when accompanied by a condition like vasa previa, an emergency could arise during labor and delivery. At that point, the doctor may have to perform resuscitation and blood transfusions.
The point of insertion can be difficult to see on ultrasounds. However, the technology to diagnose abnormal cord insertions exists and should be diligently utilized by doctors to prevent dangerous situations from arising during childbirth.
"Prevalence, Risk Factors and Outcomes of Velamentous and Marginal Cord Insertions: A Population-Based Study of 634,741 Pregnancies" by Catherine Ebbing et al., PLOS ONE, 2013.
"Prenatal Diagnosis of a Velamentous Cord Insertion Associated With a Vasa Previa" by Janet O'Brien and Karen Sheehan, Journal of Diagnostic Medical Sonography, 2001.
"Velamentous Cord Insertion in a Singleton Pregnancy: An Obscure Cause of Emergency Cesarean-A Case Report" by Juliana Rocha et al., Case Reports in Obstetrics and Gynecology, 2012.
"Velamentous Cord Insertions" by Linda Emerson, Journal of Diagnostic Medical Sonography, 2002.
"Examination of the Placenta" by Joseph Yetter, American Family Physician, 1998.Other Sources